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Phentermine and liver steatosis

Fatty liver (steatosis) is a chronic disease, which is characterized by excessive deposition of fat inside and beyond liver cells.

According to the Journal of Hepatology, alimentary obesity naturally causes increased fat deposition in liver. Almost 80% of people, having obesity or overweight, have liver steatosis.

Weight loss drug provides rapid burning of body fat and body weight normalization. Slimming pills Phentermine, combined with a low calorie diet and exercise, will help achieve optimal weight, improve a person's appearance and overall health. In anti-obesity therapy with Phentermine, fat is burned not only in problematic areas (stomach area, hips, waist, chest), but in all cells of the body, including liver cells.

Regular Phentermine pills intake for 12 weeks reduces 5% to 15% of the original weight. Fat tissue reduction, resulting from treatment with Phentermine pills, contributes to:

  • reduction of lipids amount and cholesterol level,
  • restoration of the main liver cells functions,
  • reduction of connective adipose tissue,
  • reduction of liver failure risk.

Given that Phentermine anti-obesity therapy provides fat burning, even in the most inaccessible places, these slimming pills indirectly prevent diseases, caused by steatosis. Liver dysfunction results in increased risk of the following states: steatohepatitis, fibrosis, cirrhosis, atherosclerosis, heart failure, chronic liver failure.

It is recommended to begin anti-obesity therapy in people with mild and moderate hepatic impairment with a minimum Phentermine dose of 15 mg. Approximately 30% of Phentermine is metabolized by liver. In severe hepatic impairment, Phentermine can cause sharp intoxication. Therefore, Phentermine is contraindicated in severe hepatic insufficiency.

Weight loss with Phentermine alone may not be sufficient for a full liver recovery. In such cases, obesity pharmacotherapy with Phentermine is carried out in conjunction with lipotropic agents and hepatoprotective drugs. Lipotropics help improve liver function. Lipotropic agents normalize lipid and cholesterol levels in blood plasma, and stimulate fat removal from the liver and its oxidation.

Lipotropics, mostly often used in medical practice for improving liver function, are: Choline, Inositol, Methionine, Betaine hydrochloride. Laboratory studies have shown that Phentermine has no drug interactions with lipotropics. Therefore, lipotropic agents may be included in anti-obesity therapy with Phentermine.

Hepatoprotective drugs have a detoxifying effect, contribute to liver tissue regeneration, and improve local blood flow. In medical practice, hepatoprotective drugs are classified, according to their origin:

  • hepatoprotective drugs of natural origin: Silimar, Legalon,
  • synthetic hepatoprotective drugs: Rimonabant, Silymarin, Prohepar.

Concurrent use of Phentermine with hepatoprotective drugs has no risk of drug interactions. However, hepatoprotective drugs stimulate rapid elimination of foreign substances from the body, including Phentermine. Thus, anorexigenic effect of Phentermine reduces, when these diet pills are co-administered with drugs for liver recovery.