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Despite the existence of a set of conservative and surgical treatment methods of obesity, none of them can be regarded as highly effective. Diseases related to obesity confirm extreme relevance of further study of all links of obesity pathogenesis that would help not only to optimize the obesity treatment, but also prevent the development of complications, arising as a result of excess body weight.
Acomplia drug is the first cannabinoid receptor antagonist, the pharmacological effect of which directly depends on anatomical localization of action.
Acomplia drug not only blocks endocannabinoid receptors of the hypothalamus, thereby reducing the appetite but also blocks adipocytes activation that leads to lipogenesis inhibition, insulin resistence reduction and decrease of atherogenic lipoprotein fractions.
Eliminating adverse effects of endocannabinoid system hyperactivity, Acomplia drug contributes to weight loss, improvement of lipid profile and respectively, glycemic control in patients with diabetes.
Systemic action of Acomplia drug grows with increase of dosage, however prolonged elimination half-life of active substance Rimonabant (from 5 to 9 days in young patients and up to 15 days in older patients) allows to take Acomplia drug in fixed dosage – 20mg a day.
Taking into account that concentration of active substance Rimonabant in the blood plazma starts to increase 1-3 hours after solubility of Acomplia drug in gastrointestinal tract, dosing regimen of Acomplia drug presupposes the use of one diet pill Acomplia 20mg before breakfast, once a day.
Significant Acomplia drug interactions with: antidiabetic drugs, oral contraceptives, statins, anticoagulants and antiarrhythmic medications have not been registered.
However, it should be noted that data about drug interactions and pharmacological safety of Acomplia drug were obtained in clinical trials of Acomplia, conducted under the supervision and control of specialists. So, before you include Acomplia drug in the combination of drug therapy, it is necessary to consult a professional health worker.
Favorable effect of Acomplia drug on the metabolic status of a patient (lipid spectrum) is the main distinctive feature of Acomplia drug from other drugs for weight loss ultimately, this predetermines the choice of Acomplia drug for obesity treatment, including patients with diabetes.
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